何川 博士

教授,博士生导师


联系方式:chuanhe(AT)uchicago.edu

芝加哥大学主页:http://chemistry.uchicago.edu/fac/he.shtml

2012-至今 芝加哥大学生物物理动态研究所,主任
2011-至今 北京大学合成与功能生物分子中心, 主任
2010-至今 芝加哥大学化学系,教授
2009-至今 北京大学化学与分子工程学院,讲座教授
2008-2010 美国芝加哥大学化学系, 副教授
2002-2008 美国芝加哥大学化学系, 助理教授
2000-2002 美国哈佛大学化学系,博士后
1995-2000 美国麻省理工学院化学系,理学博士

研究兴趣

  1. 研究领域涉及化学生物学、核酸化学和生物学、遗传学、细胞生物学、生物无机化学、 结构生物学、微生物学以及基因组学。
  2. 表征和研究原核生物及真核生物中DNA及RNA去甲基修复酶的结构及性质。
  3. 研究和证明多种临床感染性病原体中的全局性调控蛋白的调控机理.
  4. 研究和开发小分子药物。
  5. 金属蛋白调控机理研究与金属蛋白进化

Our research program spans a broad range of chemical biology, nucleic acid chemistry and biology, epigenetics, cell biology, bioinorganic chemistry, structural biology, microbiology, and genomics. We probe the pathways and mechanisms of nucleic acids modification and demodification. We study virulence and antibiotic resistance regulation in human pathogens. We also study selective metal ion recognition and sensing by naturally occurring and engineered proteins, and live-cell imaging of metal ions and other small molecules such as H2S, heme, and CO.

奖励与荣誉

2010 American Chemical Society Akron Section Award.
2010 Society of Biological Inorganic Chemistry Early Career Award.
2008 Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Disease Award.
2007 CACPA Distinguished Junior Faculty Award.
2006 Camille Dreyfus Teacher-Scholar Award.
2005 CAREER Award from the National Science Foundation.
2005 Cottrell Scholar by the Research Corporation.
2005 Arnold and Mabel Beckman Foundation Young Investigator.
2005 Alfred P. Sloan Research Fellowship.
2004 W. M. Keck Foundation Distinguished Young Scholar in Medical Science.
2004 G&P Foundation for Cancer Research Young Investigator.
2003 Research Corporation Research Innovation Award.
2003 Searle Scholar Award.
2001 Davison Prize for The Best Thesis in Inorganic Chemistry, MIT.
2000-2002 Damon Runyon-Walter Winchell Cancer Research Fund Postdoctoral Fellow (Harvard).
1997-1999 Merck/MIT Graduate Fellowship.
Guest Professor, University of Science and Technology of China (USTC).
Guest Professor, Nanjing University of Technology.
Joint Professor, Peking University.

近五年的代表论文

  1. Yu, M.; Hon, G. C.; Szulwach, K. E.; Song, C.-X.; Zhang, L.; Kim, A.; Li, X.; Dai, Q.; Shen, Y.; Park, B.; Min, J.-H.; Jin, P.*; Ren, B.*; He, C.* Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome. Cell2012, on-line.
  2. Yi, C.; Chen, B.; Zhang, W.; Jia, G.; Zhang, L.; Li, C. J.; Dinner, A. R.; Yang, C.-G.*; He, C.* Duplex Interrogation by a Direct DNA Repair Protein in Search of Base Damage. Nat. Struct. Mol. Biol. 2012, on-line.
  3. Zhang, L.; Lu, X.Y.; Lu, J.Y.; Liang, H.H.; Dai, Q.; Xu, G.L.; Luo, C.; Jiang, H.L.; He, C. Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat. Chem. Biol. 2012, 8, 328-330.
  4. Jia, G.; Fu, Y.; Zhao, X.; Dai, Q.; Zheng, G.; Yang, Y.; Yi, C.; Lindahl, T.; Yang, Y.-G.; He, C.* “N6-methyladesosine in nuclear RNA is a major substrate of the obesity-associated FTO” Nature Chem. Biol. 2011, 7, 885-887.
  5. Qian, Y.; Karpus, J.; Kabil, O.; Zhang, S.-Y.; Zhu, H.-L.; Banerjee, R.; Zhao, J.; He, C.* “Selective fluorescent probes for live-cell monitoring of sulfide” Nature Commun. 2011, 2, 495.
  6. He, Y.; Li, B.; Li, Z.; Liu, P.; Wang, Y.; Tang, Q.; Ding, J.; Jia, Y.; Chen, Z.; Li, L.; Sun, Y.; Li, X.; Dai, Q.; Song, C.-X.; Zhang, K.; He, C.; Xu, G.* “Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA” Science, 2011, 333, 1303-1307.
  7. Ito, S.; Shen, L.; Dai, Q.; Wu, S. C.; Collins, L. B.; Swenberg, J. A.; He, C.; Zhang, Y.* “Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine” Science, 2011, 333, 1300-1303.
  8. Song, C.-X.; Szulwach, K. E.; Fu, Y.; Dai, Q.; Yi, C.; Li, X.; Chen, C.-H.; Zhang, W.; Jian, X.; Wang, J.; Zhang, L.; Looney, T. J.; Zhang, B.; Godley, L. A.; Hicks, L. M.; Lahn, B. T.; Jin, P.*; He, C*. “Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine” Nature Biotechnol., 2011, 29, 68-72.
  9. Yi, C.; Jia, G; Hou, G.; Dai, Q.; Zhang, W.; Zheng, G.; Jian, X.; Yang, C.-G.; Cui, Q.; He, C.* “Iron-catalysed Oxidation Intermediates Captured in a DNA Repair Dioxygenase” Nature, 2010, 468, 330-333.
  10. Yang, C.-G.; Yi, C.; Duguid, E. M.; Sullivan, C. T.; Jian, X.; Rice, P. A.; He, C.* “Crystal Structures of DNA-RNA Repair Enzymes AlkB and ABH2 Bound to dsDNA” Nature, 2008, 452, 961-965.
  11. Chen, P.; Bae, T.; Williams, W. A.; Duguid, E. M.; Rice, P. A.; Schneewind, O.; He, C.* “An Oxidation Sensing Mechanism is Used by A Global Regulator of Staphylococcus aureus” Nature Chem. Biol. 2006, 2, 591-595.
  12. Chen, H.; Hu, J.; Chen, P. R.; Lan, L.; Li, Z.; Hicks, L. M.; Dinner, A. R.; He, C.* “The Pseudomonas aeruginosa Multidrug Efflux Regulator MexR Uses An Oxidation Sensing Mechanism” Proc. Natl. Acad. Sci. 2008, 105, 13586-13591.
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